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Compound Detail

CHEMBL523265

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CC(C)Oc1ccc(Oc2cccc(CCNC[C@H](O)c3cccc(Cl)c3)c2)cc1C(=O)O

Basic Information

ChEMBL ID CHEMBL523265
Phase Preclinical
Structure Type MOL
InChI Key KRDKLBROXABSCR-DEOSSOPVSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

470.0
MW (Da)
5.48
ALogP
5
HBA
3
HBD
88.0
PSA (Ų)
0.32
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28ClNO5
MW 469.97
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.78

Activity Summary

EC50 3 meas. best 8.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL4400
EC50 8.49 8.49 3.2 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.47 8.47 3.4 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.09 6.09 810.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18752946 10.1016/j.bmcl.2008.08.009 Beta-3 adrenergic receptor 3
18752946 10.1016/j.bmcl.2008.08.009 Beta-1 adrenergic receptor 1
18752946 10.1016/j.bmcl.2008.08.009 Unchecked 1

Data from ChEMBL 36 via Core Engine