Assay Detail
Functional
CHEMBL981734
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Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as cAMP accumulation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.75 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 10.08 |
| CHEMBL492006 | — | — | 1 | 7.55 |
| CHEMBL484265 | — | — | 1 | 7.19 |
| CHEMBL490222 | — | — | 1 | 6.89 |
| CHEMBL521611 | — | — | 1 | 6.85 |
| CHEMBL492005 | — | — | 1 | 6.72 |
| CHEMBL524145 | — | — | 1 | 6.72 |
| CHEMBL519985 | — | — | 1 | 6.62 |
| CHEMBL271576 | — | — | 1 | 6.55 |
| CHEMBL489200 | — | — | 1 | 6.42 |
| CHEMBL489199 | — | — | 1 | 6.29 |
| CHEMBL489201 | — | — | 1 | 6.26 |
| CHEMBL491645 | — | — | 1 | 6.21 |
| CHEMBL490415 | — | — | 1 | 6.16 |
| CHEMBL272584 | — | — | 1 | 6.14 |
| CHEMBL523265 | — | — | 1 | 6.09 |
| CHEMBL522641 | — | — | 1 | 6.08 |
| CHEMBL482627 | — | — | 1 | - |
| CHEMBL523817 | — | — | 1 | - |
| CHEMBL491634 | — | — | 1 | - |
| CHEMBL409828 | — | — | 1 | - |
| CHEMBL411234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.084 | nM | 10.08 |
| CHEMBL492006 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL484265 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL490222 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL521611 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL492005 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL524145 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL519985 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL271576 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL489200 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL489199 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL489201 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL491645 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL490415 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL272584 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL523265 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL522641 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL482627 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL523817 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL491634 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL409828 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL411234 | — | EC50 | > | 100.0 | nM | - |