Assay Detail
Functional
CHEMBL981831
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Antiviral activity against HIV2 in thymidine kinase deficient human CEM/TK- cellss
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Studies on enzyme-cleavable dialkoxymethyl-cyclosaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.33 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459226 | — | — | 1 | 6.54 |
| CHEMBL376912 | — | — | 1 | 6.11 |
| CHEMBL502960 | — | — | 1 | 5.85 |
| CHEMBL506559 | — | — | 1 | 5.62 |
| CHEMBL462601 | — | — | 1 | 5.58 |
| CHEMBL455784 | — | — | 1 | 5.44 |
| CHEMBL459227 | — | — | 1 | 5.41 |
| CHEMBL222741 | — | — | 1 | 5.35 |
| CHEMBL519208 | — | — | 1 | 5.29 |
| CHEMBL388754 | — | — | 1 | 5.20 |
| CHEMBL485209 | — | — | 1 | 5.19 |
| CHEMBL522974 | — | — | 1 | 5.14 |
| CHEMBL461547 | — | — | 1 | 5.00 |
| CHEMBL222056 | — | — | 1 | 4.82 |
| CHEMBL485037 | — | — | 1 | 4.54 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.21 |
| CHEMBL489662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459226 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL376912 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL502960 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL506559 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL462601 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL455784 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL459227 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL222741 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL519208 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL388754 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL485209 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL522974 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL461547 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL222056 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL485037 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL991 | STAVUDINE | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL489662 | — | EC50 | > | 10000.0 | nM | - |