Assay Detail
Binding
CHEMBL982026
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Inhibition of cathepsin K
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The many roles for fluorine in medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.56 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480317 | — | — | 1 | 10.82 |
| CHEMBL437501 | — | — | 1 | 9.70 |
| CHEMBL371133 | — | — | 1 | 9.40 |
| CHEMBL479755 | — | — | 1 | 8.30 |
| CHEMBL195454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480317 | — | IC50 | = | 0.015 | nM | 10.82 |
| CHEMBL437501 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL371133 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL479755 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL195454 | — | IC50 | <= | 0.005 | nM | - |