Assay Detail
Binding
CHEMBL982079
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.35 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514074 | — | — | 1 | 10.03 |
| CHEMBL477765 | — | — | 1 | 9.57 |
| CHEMBL479231 | — | — | 1 | 9.57 |
| CHEMBL477200 | — | — | 1 | 9.54 |
| CHEMBL476722 | — | — | 1 | 9.28 |
| CHEMBL476104 | — | — | 1 | 9.26 |
| CHEMBL478413 | — | — | 1 | 9.11 |
| CHEMBL478394 | — | — | 1 | 9.06 |
| CHEMBL477199 | — | — | 1 | 9.00 |
| CHEMBL515334 | — | — | 1 | 9.00 |
| CHEMBL477766 | — | — | 1 | 8.89 |
| CHEMBL517962 | — | — | 1 | 8.80 |
| CHEMBL479026 | — | — | 1 | 8.60 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 8.26 |
| CHEMBL478411 | — | — | 1 | 8.02 |
| CHEMBL478412 | — | — | 1 | 7.85 |
| CHEMBL479027 | — | — | 1 | 7.83 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.82 |
| CHEMBL476105 | — | — | 1 | 7.78 |
| CHEMBL444988 | — | — | 1 | 7.51 |
| CHEMBL477397 | — | — | 1 | 7.48 |
| CHEMBL476363 | — | — | 1 | 7.17 |
| CHEMBL514855 | — | — | 1 | 7.02 |
| CHEMBL477828 | — | — | 1 | 6.49 |
| CHEMBL477827 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514074 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL477765 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL479231 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL477200 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL476722 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL476104 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL478413 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL478394 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL477199 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL515334 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL477766 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL517962 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL479026 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL478411 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL478412 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL479027 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL49 | BUSPIRONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL476105 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL444988 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL477397 | — | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL476363 | — | Ki | = | 67.2 | nM | 7.17 |
| CHEMBL514855 | — | Ki | = | 95.2 | nM | 7.02 |
| CHEMBL477828 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL477827 | — | Ki | = | 1702.0 | nM | 5.77 |