Assay Detail
Binding
CHEMBL982102
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Displacement of [3H]SCH23390 from human cloned dopamine D1 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dopamine/serotonin receptor ligands. Part 17: a cross-target SAR approach: affinities of azecine-styled ligands for 5-HT(2A) versus D1 and D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.27 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 9.45 |
| CHEMBL245570 | — | — | 1 | 9.25 |
| CHEMBL203637 | — | — | 1 | 9.09 |
| CHEMBL441618 | — | — | 1 | 8.73 |
| CHEMBL216258 | — | — | 1 | 8.69 |
| CHEMBL231070 | — | — | 1 | 8.57 |
| CHEMBL201525 | — | — | 1 | 8.46 |
| CHEMBL508399 | — | — | 1 | 8.43 |
| CHEMBL276778 | — | — | 1 | 7.66 |
| CHEMBL380330 | — | — | 1 | 7.64 |
| CHEMBL389357 | — | — | 1 | 7.55 |
| CHEMBL459871 | — | — | 1 | 7.20 |
| CHEMBL216439 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 0.3548 | nM | 9.45 |
| CHEMBL245570 | — | Ki | = | 0.5623 | nM | 9.25 |
| CHEMBL203637 | — | Ki | = | 0.8128 | nM | 9.09 |
| CHEMBL441618 | — | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL216258 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL231070 | — | Ki | = | 2.667 | nM | 8.57 |
| CHEMBL201525 | — | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL508399 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL276778 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL380330 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL389357 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL459871 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL216439 | — | Ki | = | 158.49 | nM | 6.80 |