Assay Detail
Binding
CHEMBL982305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from alpha1 adrenergic receptor in Wistar rat cerebral cortex membrane
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.37 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176045 | FANCHININ | — | 1 | 6.16 |
| CHEMBL453291 | COCLAURINE | — | 1 | 5.97 |
| CHEMBL509109 | — | — | 1 | 5.73 |
| CHEMBL451988 | — | — | 1 | 5.69 |
| CHEMBL453292 | METHYL COCLAURINE | — | 1 | 5.63 |
| CHEMBL510364 | — | — | 1 | 5.49 |
| CHEMBL455620 | — | — | 1 | 5.49 |
| CHEMBL507843 | — | — | 1 | 5.34 |
| CHEMBL453293 | — | — | 1 | 5.29 |
| CHEMBL451987 | — | — | 1 | 5.29 |
| CHEMBL510363 | — | — | 1 | 5.23 |
| CHEMBL451722 | — | — | 1 | 5.14 |
| CHEMBL452763 | — | — | 1 | 5.12 |
| CHEMBL452500 | — | — | 1 | 5.10 |
| CHEMBL114853 | — | — | 1 | 5.07 |
| CHEMBL453024 | — | — | 1 | 5.05 |
| CHEMBL452762 | — | — | 1 | 5.02 |
| CHEMBL451723 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176045 | FANCHININ | Ki | = | 691.83 | nM | 6.16 |
| CHEMBL453291 | COCLAURINE | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL509109 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL451988 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL453292 | METHYL COCLAURINE | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL510364 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL455620 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL507843 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL453293 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL451987 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL510363 | — | Ki | = | 5888.44 | nM | 5.23 |
| CHEMBL451722 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL452763 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL452500 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL114853 | — | Ki | = | 8511.38 | nM | 5.07 |
| CHEMBL453024 | — | Ki | = | 8912.51 | nM | 5.05 |
| CHEMBL452762 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL451723 | — | Ki | = | 12022.64 | nM | 4.92 |