Assay Detail
Functional
CHEMBL982307
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Vasorelaxant activity against noradrenaline-induced contraction in Wistar rat thoracic aorta in presence of calcium
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.75 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509109 | — | — | 1 | 5.37 |
| CHEMBL455620 | — | — | 1 | 5.06 |
| CHEMBL510364 | — | — | 1 | 4.88 |
| CHEMBL451988 | — | — | 1 | 4.79 |
| CHEMBL453291 | COCLAURINE | — | 1 | 4.76 |
| CHEMBL453292 | METHYL COCLAURINE | — | 1 | 4.61 |
| CHEMBL451987 | — | — | 1 | 4.60 |
| CHEMBL176045 | FANCHININ | — | 1 | 4.53 |
| CHEMBL452500 | — | — | 1 | 4.18 |
| CHEMBL451722 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509109 | — | IC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL455620 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL510364 | — | IC50 | = | 13182.57 | nM | 4.88 |
| CHEMBL451988 | — | IC50 | = | 16218.1 | nM | 4.79 |
| CHEMBL453291 | COCLAURINE | IC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL453292 | METHYL COCLAURINE | IC50 | = | 24547.09 | nM | 4.61 |
| CHEMBL451987 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL176045 | FANCHININ | IC50 | = | 29512.09 | nM | 4.53 |
| CHEMBL452500 | — | IC50 | = | 66069.34 | nM | 4.18 |
| CHEMBL451722 | — | IC50 | = | 208929.61 | nM | - |