Assay Detail
Functional
CHEMBL982308
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Vasorelaxant activity against KCl-induced contraction in Wistar rat thoracic aorta in presence of calcium
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.77 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455620 | — | — | 1 | 5.24 |
| CHEMBL510364 | — | — | 1 | 5.12 |
| CHEMBL509109 | — | — | 1 | 4.94 |
| CHEMBL176045 | FANCHININ | — | 1 | 4.87 |
| CHEMBL451988 | — | — | 1 | 4.86 |
| CHEMBL452500 | — | — | 1 | 4.83 |
| CHEMBL453292 | METHYL COCLAURINE | — | 1 | 4.17 |
| CHEMBL451987 | — | — | 1 | 4.14 |
| CHEMBL451722 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455620 | — | IC50 | = | 5754.4 | nM | 5.24 |
| CHEMBL510364 | — | IC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL509109 | — | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL176045 | FANCHININ | IC50 | = | 13489.63 | nM | 4.87 |
| CHEMBL451988 | — | IC50 | = | 13803.84 | nM | 4.86 |
| CHEMBL452500 | — | IC50 | = | 14791.08 | nM | 4.83 |
| CHEMBL453292 | METHYL COCLAURINE | IC50 | = | 67608.3 | nM | 4.17 |
| CHEMBL451987 | — | IC50 | = | 72443.6 | nM | 4.14 |
| CHEMBL451722 | — | IC50 | = | 114815.36 | nM | - |