Assay Detail
Functional
CHEMBL982336
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-kappaB activation and NO production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466571 | — | — | 1 | 6.82 |
| CHEMBL254180 | — | — | 1 | 6.68 |
| CHEMBL399157 | — | — | 1 | 6.58 |
| CHEMBL252112 | — | — | 1 | 6.33 |
| CHEMBL4298697 | — | — | 1 | 5.70 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466571 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL254180 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL399157 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL252112 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4298697 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 4060.0 | nM | 5.39 |