Assay Detail
Binding
CHEMBL982420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction of MMP9 activity in TNF-alpha/IL1-beta-stimulated human Caco-2 cells treated 1 hr before stimulation by zymography
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.91 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481600 | — | — | 1 | 5.10 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.07 |
| CHEMBL481599 | — | — | 1 | 4.75 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481600 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL140 | CURCUMIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL481599 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 19400.0 | nM | 4.71 |