Assay Detail
Functional
CHEMBL982670
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Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.19 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520504 | — | — | 1 | 6.38 |
| CHEMBL485577 | — | — | 1 | 6.23 |
| CHEMBL484939 | — | — | 1 | 5.92 |
| CHEMBL503740 | — | — | 1 | 5.77 |
| CHEMBL500348 | — | — | 1 | 5.59 |
| CHEMBL484764 | — | — | 1 | 5.58 |
| CHEMBL484938 | — | — | 1 | 5.51 |
| CHEMBL484186 | — | — | 1 | 5.49 |
| CHEMBL448861 | — | — | 1 | 5.45 |
| CHEMBL229640 | — | — | 1 | 5.40 |
| CHEMBL483179 | — | — | 1 | 5.38 |
| CHEMBL483177 | — | — | 1 | 5.24 |
| CHEMBL484187 | — | — | 1 | 5.21 |
| CHEMBL483180 | — | — | 1 | 5.17 |
| CHEMBL520487 | — | — | 1 | 5.16 |
| CHEMBL376797 | ASCIDIATHIAZONE A METHYL ESTER | — | 1 | 4.92 |
| CHEMBL448281 | — | — | 1 | 4.85 |
| CHEMBL226554 | ASCIDIATHIAZONE B | — | 1 | 4.80 |
| CHEMBL485212 | — | — | 1 | 4.57 |
| CHEMBL520670 | — | — | 1 | 4.46 |
| CHEMBL226553 | ACIDIATHIAZONE A | — | 1 | 4.14 |
| CHEMBL483167 | — | — | 1 | 4.04 |
| CHEMBL483169 | — | — | 1 | 4.01 |
| CHEMBL483168 | — | — | 1 | - |
| CHEMBL72628 | 2-PICOLINIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520504 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL485577 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL484939 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL503740 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL500348 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL484764 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL484938 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL484186 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL448861 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL229640 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL483179 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL483177 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL484187 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL483180 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL520487 | — | IC50 | = | 6870.0 | nM | 5.16 |
| CHEMBL376797 | ASCIDIATHIAZONE A METHYL ESTER | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL448281 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL226554 | ASCIDIATHIAZONE B | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL485212 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL520670 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL226553 | ACIDIATHIAZONE A | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL483167 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL483169 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL483168 | — | IC50 | - | — | - | |
| CHEMBL72628 | 2-PICOLINIC ACID | IC50 | - | — | - |