Assay Detail
Binding
CHEMBL982797
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Displacement of [3H]DAMGO from mu opioid receptor in rat brain membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.24 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445869 | — | — | 1 | 8.99 |
| CHEMBL503771 | — | — | 1 | 8.65 |
| CHEMBL501892 | — | — | 1 | 7.53 |
| CHEMBL506821 | — | — | 1 | 6.67 |
| CHEMBL510976 | — | — | 1 | 6.39 |
| CHEMBL501939 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445869 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL503771 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL501892 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL506821 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL510976 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL501939 | — | Ki | = | 5850.0 | nM | 5.23 |