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Assay Detail

CHEMBL982825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL3998)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors.
Andrić D, Roglić G, Sukalović V, Soskić V, Kostić-Rajacić S.
Eur J Med Chem (2008) 43 : 1696 -1705
PubMed 18006194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.42 9.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445347 1 9.25
CHEMBL510055 1 8.26
CHEMBL488977 1 8.24
CHEMBL491233 1 7.88
CHEMBL483247 1 7.72
CHEMBL488555 1 7.57
CHEMBL489599 1 7.22
CHEMBL485499 1 7.21
CHEMBL483864 1 7.07
CHEMBL492042 1 7.07
CHEMBL491232 1 6.86
CHEMBL485298 1 6.70
CHEMBL521581 1 6.56
CHEMBL520019 1 6.26
CHEMBL522639 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445347 Ki = 0.56 nM 9.25
CHEMBL510055 Ki = 5.49 nM 8.26
CHEMBL488977 Ki = 5.77 nM 8.24
CHEMBL491233 Ki = 13.1 nM 7.88
CHEMBL483247 Ki = 19.1 nM 7.72
CHEMBL488555 Ki = 26.7 nM 7.57
CHEMBL489599 Ki = 59.7 nM 7.22
CHEMBL485499 Ki = 61.9 nM 7.21
CHEMBL483864 Ki = 84.7 nM 7.07
CHEMBL492042 Ki = 84.7 nM 7.07
CHEMBL491232 Ki = 138.0 nM 6.86
CHEMBL485298 Ki = 200.0 nM 6.70
CHEMBL521581 Ki = 273.0 nM 6.56
CHEMBL520019 Ki = 550.0 nM 6.26
CHEMBL522639 Ki > 1000.0 nM -