Assay Detail
Functional
CHEMBL982902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as inhibition of 5-hydroxytryptamine-induced increase in [35S]GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.49 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476722 | — | — | 1 | 8.89 |
| CHEMBL477200 | — | — | 1 | 8.77 |
| CHEMBL514074 | — | — | 1 | 8.18 |
| CHEMBL516590 | — | — | 1 | 8.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476722 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL477200 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL514074 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL516590 | — | Ki | = | 7.4 | nM | 8.13 |