Assay Detail
Binding
CHEMBL982933
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Inhibition of human serum BChE by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.34 |
| CHEMBL474268 | — | — | 1 | 6.86 |
| CHEMBL473866 | — | — | 1 | 6.72 |
| CHEMBL478667 | — | — | 1 | 6.68 |
| CHEMBL478666 | CARBACRINE | — | 1 | 6.53 |
| CHEMBL191758 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL474268 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL473866 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL478667 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL478666 | CARBACRINE | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL191758 | — | IC50 | = | 2580.0 | nM | 5.59 |