Assay Detail
Functional
CHEMBL982937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antioxidant activity against tert-butyl hydroperoxide-induced ROS evoked cell death in human SH-SY5Y cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.37 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46723 | — | — | 1 | 7.16 |
| CHEMBL478666 | CARBACRINE | — | 1 | 4.64 |
| CHEMBL153 | TROLOX | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46723 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL478666 | CARBACRINE | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL153 | TROLOX | IC50 | = | 49550.0 | nM | 4.30 |