Assay Detail
Functional
CHEMBL983169
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Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tricin from a malagasy connaraceous plant with potent antihistaminic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.44 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454320 | TRICIN | — | 1 | 5.32 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.24 |
| CHEMBL55415 | SCUTELLAREIN | — | 1 | 4.17 |
| CHEMBL354496 | — | — | 1 | 4.01 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | - |
| CHEMBL348436 | CIRSIMARITIN | — | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL73930 | TANGERETIN | — | 1 | - |
| CHEMBL438292 | — | — | 1 | - |
| CHEMBL312790 | SIDERITIFLAVONE | — | 1 | - |
| CHEMBL117 | CHRYSIN | — | 1 | - |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | — | 1 | - |
| CHEMBL76426 | — | — | 1 | - |
| CHEMBL464339 | 3',5'-DIMETHOXYFLAVONE | — | 1 | - |
| CHEMBL464545 | — | — | 1 | - |
| CHEMBL464546 | — | — | 1 | - |
| CHEMBL444461 | — | — | 1 | - |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | - |
| CHEMBL486590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454320 | TRICIN | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL55415 | SCUTELLAREIN | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL354496 | — | IC50 | = | 97500.0 | nM | 4.01 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 179000.0 | nM | - |
| CHEMBL348436 | CIRSIMARITIN | IC50 | = | 161000.0 | nM | - |
| CHEMBL28 | APIGENIN | IC50 | = | 124000.0 | nM | - |
| CHEMBL73930 | TANGERETIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL438292 | — | IC50 | = | 203000.0 | nM | - |
| CHEMBL312790 | SIDERITIFLAVONE | IC50 | > | 500000.0 | nM | - |
| CHEMBL117 | CHRYSIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | IC50 | > | 500000.0 | nM | - |
| CHEMBL76426 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL464339 | 3',5'-DIMETHOXYFLAVONE | IC50 | > | 500000.0 | nM | - |
| CHEMBL464545 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL464546 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL444461 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL74 | CROMOLYN SODIUM | IC50 | = | 1540000.0 | nM | - |
| CHEMBL486590 | — | IC50 | = | 424000.0 | nM | - |