Assay Detail

CHEMBL983350

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Functional

Inhibition of HIV1 LAI replication in C8166 cells after 4 days by ELISA

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Cell Type	C8166
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae.

Li E, Tian R, Liu S, Chen X, Guo L, Che Y.
J Nat Prod (2008) 71 : 664 -668
PubMed 18303847 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.44	8.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1735	INDINAVIR SULFATE	4.0	1	8.09
CHEMBL446931	PESTALOTHEOL C	—	1	4.79

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1735	INDINAVIR SULFATE	EC50	=	8.18	nM	8.09
CHEMBL446931	PESTALOTHEOL C	EC50	=	16100.0	nM	4.79