Assay Detail
Functional
CHEMBL983413
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Cytotoxicity against human HCT116 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.42 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494804 | — | — | 1 | 6.70 |
| CHEMBL398866 | — | — | 1 | 6.41 |
| CHEMBL454434 | — | — | 1 | 6.41 |
| CHEMBL493620 | (+/-)-TYLOPHORINE | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494804 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL398866 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL454434 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL493620 | (+/-)-TYLOPHORINE | IC50 | = | 670.0 | nM | 6.17 |