Assay Detail
Functional
CHEMBL983446
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.94 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215434 | PHYSALIN F | — | 1 | 6.48 |
| CHEMBL504404 | PHYSALIN B | — | 1 | 6.08 |
| CHEMBL75589 | OMBUINE | — | 1 | 5.65 |
| CHEMBL504741 | PHYSALIN A | — | 1 | 5.59 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.13 |
| CHEMBL492224 | PHYSALIN O | — | 1 | 4.77 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 4.19 |
| CHEMBL502380 | ISOPHYSALIN G | — | 1 | 4.19 |
| CHEMBL504052 | PHYSALIN Z | — | 1 | 4.12 |
| CHEMBL503428 | PHYSALIN Y | — | 1 | 4.10 |
| CHEMBL501438 | PHYSALIN I | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215434 | PHYSALIN F | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL504404 | PHYSALIN B | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL75589 | OMBUINE | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL504741 | PHYSALIN A | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL492224 | PHYSALIN O | IC50 | = | 17110.0 | nM | 4.77 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 64340.0 | nM | 4.19 |
| CHEMBL502380 | ISOPHYSALIN G | IC50 | = | 64010.0 | nM | 4.19 |
| CHEMBL504052 | PHYSALIN Z | IC50 | = | 75720.0 | nM | 4.12 |
| CHEMBL503428 | PHYSALIN Y | IC50 | = | 79230.0 | nM | 4.10 |
| CHEMBL501438 | PHYSALIN I | IC50 | = | 83960.0 | nM | 4.08 |