Assay Detail
Functional
CHEMBL983467
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Antiproliferative activity against human Molt4/C8 cells after 2 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.67 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227987 | — | — | 1 | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.80 |
| CHEMBL492212 | — | — | 1 | 7.32 |
| CHEMBL271388 | — | — | 1 | 7.24 |
| CHEMBL489153 | — | — | 1 | 7.21 |
| CHEMBL490384 | — | — | 1 | 7.07 |
| CHEMBL522420 | — | — | 1 | 6.85 |
| CHEMBL490180 | — | — | 1 | 6.62 |
| CHEMBL491395 | — | — | 1 | 6.51 |
| CHEMBL523145 | — | — | 1 | 6.33 |
| CHEMBL271171 | — | — | 1 | 6.20 |
| CHEMBL492213 | — | — | 1 | 6.17 |
| CHEMBL490615 | — | — | 1 | 5.75 |
| CHEMBL491397 | — | — | 1 | 5.57 |
| CHEMBL523979 | — | — | 1 | 5.36 |
| CHEMBL364280 | — | — | 1 | - |
| CHEMBL491598 | — | — | 1 | - |
| CHEMBL490616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227987 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL492212 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL271388 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL489153 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL490384 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL522420 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL490180 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL491395 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL523145 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL271171 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL492213 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL490615 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL491397 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL523979 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL364280 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490616 | — | IC50 | > | 10000.0 | nM | - |