Assay Detail
ADMET
CHEMBL983468
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Antiproliferative activity against human CEM cells after 2 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.69 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.72 |
| CHEMBL227987 | — | — | 1 | 8.11 |
| CHEMBL271388 | — | — | 1 | 7.15 |
| CHEMBL492212 | — | — | 1 | 7.11 |
| CHEMBL489153 | — | — | 1 | 7.11 |
| CHEMBL522420 | — | — | 1 | 7.06 |
| CHEMBL490384 | — | — | 1 | 6.92 |
| CHEMBL490180 | — | — | 1 | 6.68 |
| CHEMBL271171 | — | — | 1 | 6.50 |
| CHEMBL491395 | — | — | 1 | 6.34 |
| CHEMBL492213 | — | — | 1 | 5.85 |
| CHEMBL523145 | — | — | 1 | 5.77 |
| CHEMBL490615 | — | — | 1 | 5.17 |
| CHEMBL523979 | — | — | 1 | 5.11 |
| CHEMBL364280 | — | — | 1 | - |
| CHEMBL491598 | — | — | 1 | - |
| CHEMBL491397 | — | — | 1 | - |
| CHEMBL490616 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL227987 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL271388 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL492212 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL489153 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL522420 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL490384 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL490180 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL271171 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL491395 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL492213 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL523145 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL490615 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL523979 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL364280 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490616 | — | IC50 | > | 10000.0 | nM | - |