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Assay Detail

CHEMBL983535

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of amyloid beta42 fibril formation by thioflavin T formation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Byun JH, Kim H, Kim Y, Mook-Jung I, Kim DJ, Lee WK, Yoo KH.
Bioorg Med Chem Lett (2008) 18 : 5591 -5593
PubMed 18793854 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.06 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL524141 1 7.16
CHEMBL523824 1 7.10
CHEMBL509088 1 6.89
CHEMBL489792 1 6.80
CHEMBL491203 1 6.80
CHEMBL524114 1 6.77
CHEMBL446870 1 6.70
CHEMBL489979 1 6.33
CHEMBL521929 1 6.28
CHEMBL489994 1 6.10
CHEMBL140 CURCUMIN 3.0 1 6.10
CHEMBL492217 1 6.09
CHEMBL492024 1 6.09
CHEMBL490799 1 5.87
CHEMBL489978 1 5.70
CHEMBL490808 1 5.67
CHEMBL491407 1 5.66
CHEMBL492216 1 5.64
CHEMBL492023 1 5.55
CHEMBL444393 1 5.53
CHEMBL490798 1 5.49
CHEMBL491406 1 5.46
CHEMBL443097 1 5.44
CHEMBL490806 1 5.26
CHEMBL418455 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL524141 IC50 = 70.0 nM 7.16
CHEMBL523824 IC50 = 80.0 nM 7.10
CHEMBL509088 IC50 = 130.0 nM 6.89
CHEMBL489792 IC50 = 160.0 nM 6.80
CHEMBL491203 IC50 = 160.0 nM 6.80
CHEMBL524114 IC50 = 170.0 nM 6.77
CHEMBL446870 IC50 = 200.0 nM 6.70
CHEMBL489979 IC50 = 470.0 nM 6.33
CHEMBL521929 IC50 = 530.0 nM 6.28
CHEMBL489994 IC50 = 800.0 nM 6.10
CHEMBL140 CURCUMIN IC50 = 800.0 nM 6.10
CHEMBL492217 IC50 = 810.0 nM 6.09
CHEMBL492024 IC50 = 820.0 nM 6.09
CHEMBL490799 IC50 = 1340.0 nM 5.87
CHEMBL489978 IC50 = 1980.0 nM 5.70
CHEMBL490808 IC50 = 2160.0 nM 5.67
CHEMBL491407 IC50 = 2190.0 nM 5.66
CHEMBL492216 IC50 = 2300.0 nM 5.64
CHEMBL492023 IC50 = 2800.0 nM 5.55
CHEMBL444393 IC50 = 2950.0 nM 5.53
CHEMBL490798 IC50 = 3210.0 nM 5.49
CHEMBL491406 IC50 = 3440.0 nM 5.46
CHEMBL443097 IC50 = 3620.0 nM 5.44
CHEMBL490806 IC50 = 5440.0 nM 5.26
CHEMBL418455 IC50 = 8000.0 nM 5.10