Assay Detail
Functional
CHEMBL983583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at muscarinic M2 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491209 | — | — | 1 | 7.92 |
| CHEMBL514689 | — | — | 1 | - |
| CHEMBL522460 | — | — | 1 | - |
| CHEMBL491818 | — | — | 1 | - |
| CHEMBL489576 | — | — | 1 | - |
| CHEMBL521914 | — | — | 1 | - |
| CHEMBL490797 | — | — | 1 | - |
| CHEMBL522451 | — | — | 1 | - |
| CHEMBL490598 | — | — | 1 | - |
| CHEMBL491208 | — | — | 1 | - |
| CHEMBL478034 | — | — | 1 | - |
| CHEMBL515489 | — | — | 1 | - |
| CHEMBL477821 | — | — | 1 | - |
| CHEMBL518747 | — | — | 1 | - |
| CHEMBL478662 | — | — | 1 | - |
| CHEMBL490597 | — | — | 1 | - |
| CHEMBL523657 | — | — | 1 | - |
| CHEMBL476990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491209 | — | EC50 | = | 11.9 | nM | 7.92 |
| CHEMBL514689 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL522460 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL491818 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL489576 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL521914 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL490797 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL522451 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL490598 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL491208 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL478034 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL515489 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL477821 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL518747 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL478662 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL490597 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL523657 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL476990 | — | EC50 | > | 50000.0 | nM | - |