Assay Detail
Binding
CHEMBL983677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.36 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489788 | — | — | 1 | 9.40 |
| CHEMBL490825 | — | — | 1 | 9.30 |
| CHEMBL523659 | — | — | 1 | 9.15 |
| CHEMBL492021 | — | — | 1 | 9.10 |
| CHEMBL522432 | — | — | 1 | 9.10 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 9.05 |
| CHEMBL67860 | — | — | 1 | 8.96 |
| CHEMBL492228 | — | — | 1 | 8.96 |
| CHEMBL491206 | — | — | 1 | 8.48 |
| CHEMBL522264 | — | — | 1 | 8.48 |
| CHEMBL489781 | — | — | 1 | 7.52 |
| CHEMBL520127 | — | — | 1 | 7.43 |
| CHEMBL506863 | — | — | 1 | 6.96 |
| CHEMBL491205 | — | — | 1 | 6.86 |
| CHEMBL446389 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489788 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL490825 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL523659 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL492021 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL522432 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL67860 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL492228 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL491206 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL522264 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL489781 | — | EC50 | = | 30.5 | nM | 7.52 |
| CHEMBL520127 | — | EC50 | = | 37.5 | nM | 7.43 |
| CHEMBL506863 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL491205 | — | EC50 | = | 137.7 | nM | 6.86 |
| CHEMBL446389 | — | EC50 | = | 245.8 | nM | 6.61 |