Assay Detail
Binding
CHEMBL983679
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Displacement of [3H]progesterone from progesterone receptor in human T47D cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.85 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492021 | — | — | 1 | 8.62 |
| CHEMBL522432 | — | — | 1 | 8.47 |
| CHEMBL523659 | — | — | 1 | 8.42 |
| CHEMBL491206 | — | — | 1 | 7.97 |
| CHEMBL483246 | — | — | 1 | 7.55 |
| CHEMBL521141 | — | — | 1 | 7.44 |
| CHEMBL520169 | — | — | 1 | 7.22 |
| CHEMBL521760 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492021 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL522432 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL523659 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL491206 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL483246 | — | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL521141 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL520169 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL521760 | — | IC50 | = | 75.0 | nM | 7.12 |