Assay Detail
Functional
CHEMBL983788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cholesterol ester synthesis in mouse macrophages assessed as lipid droplet accumulation
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a focused library of beauveriolides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 6.27 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446298 | — | — | 1 | 7.70 |
| CHEMBL449307 | — | — | 1 | 7.70 |
| CHEMBL455036 | — | — | 1 | 7.70 |
| CHEMBL505016 | — | — | 1 | 7.40 |
| CHEMBL504602 | — | — | 1 | 7.16 |
| CHEMBL507187 | — | — | 1 | 7.10 |
| CHEMBL449899 | — | — | 1 | 7.10 |
| CHEMBL447073 | — | — | 1 | 6.96 |
| CHEMBL447246 | — | — | 1 | 6.96 |
| CHEMBL475072 | — | — | 1 | 6.96 |
| CHEMBL505770 | — | — | 1 | 6.80 |
| CHEMBL448413 | — | — | 1 | 6.62 |
| CHEMBL475276 | — | — | 1 | 6.52 |
| CHEMBL409855 | BEAUVERIOLIDE III | — | 1 | 6.40 |
| CHEMBL478840 | — | — | 1 | 6.32 |
| CHEMBL516093 | BEAUVERIOLIDE I | — | 1 | 6.22 |
| CHEMBL478003 | — | — | 1 | 6.19 |
| CHEMBL478002 | — | — | 1 | 6.10 |
| CHEMBL475912 | — | — | 1 | 6.05 |
| CHEMBL506828 | — | — | 1 | 6.05 |
| CHEMBL513885 | — | — | 1 | 6.00 |
| CHEMBL470774 | — | — | 1 | 5.77 |
| CHEMBL446132 | — | — | 1 | 5.70 |
| CHEMBL499317 | — | — | 1 | 5.70 |
| CHEMBL510857 | — | — | 1 | 5.64 |
| CHEMBL518127 | — | — | 1 | 5.60 |
| CHEMBL476956 | — | — | 1 | 5.12 |
| CHEMBL514715 | — | — | 1 | 5.12 |
| CHEMBL475480 | — | — | 1 | 5.03 |
| CHEMBL514859 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446298 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL455036 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL449307 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL505016 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL504602 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL507187 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL449899 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL447073 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL447246 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL475072 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL505770 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL448413 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL475276 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL409855 | BEAUVERIOLIDE III | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL478840 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL516093 | BEAUVERIOLIDE I | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL478003 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL478002 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL475912 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL506828 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL513885 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL470774 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL446132 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL499317 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL510857 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL518127 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL476956 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL514715 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL475480 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL514859 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL476955 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL514062 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL447007 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL517064 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL478815 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL517670 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL515601 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL444820 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL514244 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL475479 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL515806 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL475911 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL515963 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL478214 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL478627 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL477162 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL515748 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL469315 | — | IC50 | > | 20000.0 | nM | - |