Assay Detail
Binding
CHEMBL983955
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Inhibition of human recombinant IKK1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.38 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483165 | — | — | 1 | 7.90 |
| CHEMBL482540 | — | — | 1 | 7.50 |
| CHEMBL482746 | — | — | 1 | 7.30 |
| CHEMBL520473 | — | — | 1 | 6.90 |
| CHEMBL482747 | — | — | 1 | 6.90 |
| CHEMBL519028 | — | — | 1 | 6.80 |
| CHEMBL519965 | — | — | 1 | 6.80 |
| CHEMBL473080 | — | — | 1 | 6.60 |
| CHEMBL482539 | — | — | 1 | 6.50 |
| CHEMBL483557 | — | — | 1 | 6.50 |
| CHEMBL504261 | — | — | 1 | 6.40 |
| CHEMBL453707 | — | — | 1 | 6.10 |
| CHEMBL520954 | — | — | 1 | 6.10 |
| CHEMBL483166 | — | — | 1 | 6.00 |
| CHEMBL520655 | — | — | 1 | 5.90 |
| CHEMBL482553 | — | — | 1 | 5.90 |
| CHEMBL520308 | — | — | 1 | 5.50 |
| CHEMBL482538 | — | — | 1 | 5.40 |
| CHEMBL485145 | — | — | 1 | 5.40 |
| CHEMBL484966 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483165 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL482540 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL482746 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL520473 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL482747 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL519028 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL519965 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL473080 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL482539 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL483557 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL504261 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL453707 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL520954 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL483166 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL520655 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL482553 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL520308 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL482538 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL485145 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL484966 | — | IC50 | = | 7943.28 | nM | 5.10 |