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Assay Detail

CHEMBL983958

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Aurora B kinase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Aurora kinase B (CHEMBL2185)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Liddle J, Bamborough P, Barker MD, Campos S, Cousins RP, Cutler GJ, Hobbs H, Holmes DS, Ioannou C, Mellor GW, Morse MA, Payne JJ, Pritchard JM, Smith KJ, Tape DT, Whitworth C, Williamson RA.
Bioorg Med Chem Lett (2009) 19 : 2504 -2508
PubMed 19349179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.80 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520308 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520308 IC50 = 1584.89 nM 5.80