Assay Detail
Functional
CHEMBL984035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 infected in CEM-SS cells assessed as virus-induced cytopathic effect by XTT assay
7
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 2 | 5.91 | 6.03 |
| IC50 | 2 | 4.56 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511557 | BUCHAPINE | — | 2 | 6.03 |
| CHEMBL444821 | — | — | 2 | 5.79 |
| CHEMBL466983 | ROXIAMINE A | — | 1 | - |
| CHEMBL468662 | ROXIAMINE C | — | 1 | - |
| CHEMBL466984 | ROXIAMINE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511557 | BUCHAPINE | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL444821 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL444821 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL511557 | BUCHAPINE | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL466983 | ROXIAMINE A | Activity | - | — | - | |
| CHEMBL468662 | ROXIAMINE C | Activity | - | — | - | |
| CHEMBL466984 | ROXIAMINE B | Activity | - | — | - |