Assay Detail
Functional
CHEMBL984134
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Inhibition of LPS-induced TNFalpha production in human whole blood
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.79 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491462 | — | — | 1 | 7.66 |
| CHEMBL510740 | — | — | 1 | 7.46 |
| CHEMBL451523 | — | — | 1 | 7.34 |
| CHEMBL505951 | — | — | 1 | 7.15 |
| CHEMBL451104 | — | — | 1 | 7.13 |
| CHEMBL453999 | — | — | 1 | 7.01 |
| CHEMBL448568 | — | — | 1 | 7.01 |
| CHEMBL454833 | — | — | 1 | 6.96 |
| CHEMBL453729 | — | — | 1 | 6.96 |
| CHEMBL504583 | — | — | 1 | 6.92 |
| CHEMBL523978 | — | — | 1 | 6.85 |
| CHEMBL470859 | — | — | 1 | 6.75 |
| CHEMBL381743 | — | — | 1 | 6.66 |
| CHEMBL410761 | — | — | 1 | 6.64 |
| CHEMBL499149 | — | — | 1 | 6.46 |
| CHEMBL518150 | — | — | 1 | 6.16 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 6.11 |
| CHEMBL104749 | — | — | 1 | 5.00 |
| CHEMBL473880 | — | — | 1 | - |
| CHEMBL519161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491462 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL510740 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL451523 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL505951 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL451104 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL453999 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL448568 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL454833 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL453729 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL504583 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL523978 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL470859 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL381743 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL410761 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL499149 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL518150 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL104749 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL473880 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL519161 | — | IC50 | - | — | - |