Assay Detail
Binding
CHEMBL984215
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Displacement of [3H]PK11195 from TSPO in rat cortex
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The translocator protein (18 kDa): central nervous system disease and drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.50 | 9.04 |
| Kd | 1 | 9.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | — | 1 | 9.22 |
| CHEMBL205767 | — | — | 1 | 9.04 |
| CHEMBL63154 | — | — | 1 | 8.30 |
| CHEMBL512306 | DPA-714 | 2.0 | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL205767 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL63154 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL512306 | DPA-714 | Ki | = | 7.0 | nM | 8.15 |