Assay Detail
Functional
CHEMBL984594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of differentiation of human HL-60 cells promyelocytes to monocytes after 4 days by NBT reduction assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones--weak agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.70 |
| CHEMBL261197 | — | — | 1 | 8.70 |
| CHEMBL263638 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL261197 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL263638 | — | EC50 | = | 4.0 | nM | 8.40 |