Assay Detail
Binding
CHEMBL984670
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Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.70 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162296 | — | — | 1 | 7.00 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.50 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162296 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | Kd | = | 24900.0 | nM | 4.60 |