Assay Detail
Functional
CHEMBL984808
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Antimicrobial activity against Mycobacterium intracellular ATCC 23068
12
Total Activities
4
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium intracellulare |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Mycobacterium intracellulare (CHEMBL612640) ↗| Type | ORGANISM |
| Organism | Mycobacterium intracellulare |
Publication
2-N-Methyl modifications and SAR studies of manzamine A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.75 |
| MIC | 4 | - | - |
| MBC | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403233 | MANZAMINE A | — | 3 | 6.75 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 3 | 5.96 |
| CHEMBL443420 | — | — | 3 | 4.75 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403233 | MANZAMINE A | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL443420 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL403233 | MANZAMINE A | MIC | = | 360.0 | nM | - |
| CHEMBL403233 | MANZAMINE A | MBC | = | 2.84 | uM | - |
| CHEMBL443420 | — | MIC | = | 44500.0 | nM | - |
| CHEMBL443420 | — | MBC | = | 44.5 | uM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - | |
| CHEMBL267345 | AMPHOTERICIN B | MIC | - | — | - | |
| CHEMBL267345 | AMPHOTERICIN B | MBC | - | — | - | |
| CHEMBL8 | CIPROFLOXACIN | MIC | = | 1500.0 | nM | - |
| CHEMBL8 | CIPROFLOXACIN | MBC | = | 3.0 | uM | - |