Assay Detail
Binding
CHEMBL985173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat Nav1.2 channel expressed in Xenopus oocytes by whole cell voltage clamp technique
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 2 subunit alpha (CHEMBL3399) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 10 | - | - |
| Kd | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525818 | — | — | 1 | 8.52 |
| CHEMBL508113 | — | — | 1 | - |
| CHEMBL525208 | — | — | 1 | - |
| CHEMBL525941 | — | — | 1 | - |
| CHEMBL524475 | — | — | 1 | - |
| CHEMBL505134 | — | — | 1 | - |
| CHEMBL506946 | — | — | 1 | - |
| CHEMBL470273 | — | — | 1 | - |
| CHEMBL503290 | — | — | 1 | - |
| CHEMBL524481 | — | — | 1 | - |
| CHEMBL501301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525818 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL508113 | — | Activity | - | — | - | |
| CHEMBL525208 | — | Activity | - | — | - | |
| CHEMBL525941 | — | Activity | - | — | - | |
| CHEMBL524475 | — | Activity | - | — | - | |
| CHEMBL505134 | — | Activity | - | — | - | |
| CHEMBL506946 | — | Activity | - | — | - | |
| CHEMBL470273 | — | Activity | - | — | - | |
| CHEMBL503290 | — | Activity | - | — | - | |
| CHEMBL524481 | — | Activity | - | — | - | |
| CHEMBL501301 | — | Activity | - | — | - |