Assay Detail
Functional
CHEMBL985339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.43 | 5.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.82 |
| CHEMBL445026 | — | — | 1 | 5.15 |
| CHEMBL500090 | — | — | 1 | 4.77 |
| CHEMBL450375 | — | — | 1 | 4.64 |
| CHEMBL499125 | — | — | 1 | 4.60 |
| CHEMBL505620 | — | — | 1 | 4.46 |
| CHEMBL445861 | — | — | 1 | 4.44 |
| CHEMBL448464 | — | — | 1 | 4.43 |
| CHEMBL511702 | — | — | 1 | 4.35 |
| CHEMBL456731 | — | — | 1 | 4.33 |
| CHEMBL444922 | — | — | 1 | 4.19 |
| CHEMBL458485 | — | — | 1 | 4.16 |
| CHEMBL456513 | — | — | 1 | 4.15 |
| CHEMBL507149 | — | — | 1 | 4.10 |
| CHEMBL460176 | — | — | 1 | 4.06 |
| CHEMBL448878 | — | — | 1 | 4.04 |
| CHEMBL454536 | — | — | 1 | 4.04 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.04 |
| CHEMBL462519 | — | — | 1 | - |
| CHEMBL512222 | — | — | 1 | - |
| CHEMBL501820 | — | — | 1 | - |
| CHEMBL460607 | — | — | 1 | - |
| CHEMBL460390 | — | — | 1 | - |
| CHEMBL506460 | — | — | 1 | - |
| CHEMBL446494 | — | — | 1 | - |
| CHEMBL448793 | — | — | 1 | - |
| CHEMBL461886 | — | — | 1 | - |
| CHEMBL461887 | — | — | 1 | - |
| CHEMBL460760 | — | — | 1 | - |
| CHEMBL462520 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL445026 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL500090 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL450375 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL499125 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL505620 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL445861 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL448464 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL511702 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL456731 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL444922 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL458485 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL456513 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL507149 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL460176 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL454536 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL448878 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL660 | AMANTADINE | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL456398 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL458070 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL508777 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL501363 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL462520 | — | IC50 | = | 178000.0 | nM | - |
| CHEMBL460760 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL461887 | — | Activity | - | — | - | |
| CHEMBL461886 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL448793 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL446494 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL506460 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL460390 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL460607 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL501820 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL512222 | — | IC50 | > | 200000000.0 | nM | - |
| CHEMBL462519 | — | IC50 | = | 138000.0 | nM | - |