Assay Detail
Functional
CHEMBL985388
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Cytotoxicity against IL3-dependent mouse FL5.12 cells overexpressing human Bcl-XL assessed as cell viability after 24 hrs by MTS assay in absence of serum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.31 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508865 | — | — | 1 | 9.15 |
| CHEMBL448740 | — | — | 1 | 9.05 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 8.38 |
| CHEMBL451683 | — | — | 1 | 8.30 |
| CHEMBL501889 | — | — | 1 | 7.92 |
| CHEMBL473870 | — | — | 1 | 7.68 |
| CHEMBL466090 | — | — | 1 | 7.54 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.52 |
| CHEMBL452892 | — | — | 1 | 7.26 |
| CHEMBL510351 | — | — | 1 | 6.91 |
| CHEMBL469778 | — | — | 1 | 6.84 |
| CHEMBL444481 | — | — | 1 | 6.65 |
| CHEMBL510761 | — | — | 1 | 6.48 |
| CHEMBL508210 | — | — | 1 | 6.38 |
| CHEMBL449676 | — | — | 1 | 6.09 |
| CHEMBL508864 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508865 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL448740 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL451683 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL501889 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL473870 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL466090 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL376408 | ABT 737 | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL452892 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL510351 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL469778 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL444481 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL510761 | — | EC50 | = | 329.0 | nM | 6.48 |
| CHEMBL508210 | — | EC50 | = | 415.0 | nM | 6.38 |
| CHEMBL449676 | — | EC50 | = | 805.0 | nM | 6.09 |
| CHEMBL508864 | — | EC50 | = | 15000.0 | nM | 4.82 |