Assay Detail
Functional
CHEMBL985389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H146 cells assessed as cell viability after 48 hrs in presence of 10% human serum
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H146 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.12 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466090 | — | — | 1 | 7.59 |
| CHEMBL501889 | — | — | 1 | 7.41 |
| CHEMBL451683 | — | — | 1 | 7.29 |
| CHEMBL508865 | — | — | 1 | 7.23 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.06 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.06 |
| CHEMBL448740 | — | — | 1 | 7.01 |
| CHEMBL473870 | — | — | 1 | 6.70 |
| CHEMBL452892 | — | — | 1 | 6.58 |
| CHEMBL508093 | — | — | 1 | 6.21 |
| CHEMBL469778 | — | — | 1 | 6.16 |
| CHEMBL444481 | — | — | 1 | 5.71 |
| CHEMBL510761 | — | — | 1 | 5.70 |
| CHEMBL510351 | — | — | 1 | 5.61 |
| CHEMBL449676 | — | — | 1 | 5.29 |
| CHEMBL509460 | — | — | 1 | 4.54 |
| CHEMBL500815 | — | — | 1 | 4.48 |
| CHEMBL508210 | — | — | 1 | 4.46 |
| CHEMBL508864 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466090 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL501889 | — | EC50 | = | 39.4 | nM | 7.41 |
| CHEMBL451683 | — | EC50 | = | 51.9 | nM | 7.29 |
| CHEMBL508865 | — | EC50 | = | 58.9 | nM | 7.23 |
| CHEMBL376408 | ABT 737 | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 86.7 | nM | 7.06 |
| CHEMBL448740 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL473870 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL452892 | — | EC50 | = | 266.0 | nM | 6.58 |
| CHEMBL508093 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL469778 | — | EC50 | = | 691.0 | nM | 6.16 |
| CHEMBL444481 | — | EC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL510761 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL510351 | — | EC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL449676 | — | EC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL509460 | — | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL500815 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL508210 | — | EC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL508864 | — | EC50 | = | 78700.0 | nM | 4.10 |