Assay Detail
Binding
CHEMBL985687
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.31 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477362 | — | — | 1 | 7.82 |
| CHEMBL517675 | — | — | 1 | 7.75 |
| CHEMBL451358 | — | — | 1 | 7.75 |
| CHEMBL479054 | — | — | 1 | 7.52 |
| CHEMBL191941 | — | — | 1 | 7.40 |
| CHEMBL476536 | — | — | 1 | 7.33 |
| CHEMBL516289 | — | — | 1 | 7.32 |
| CHEMBL478415 | — | — | 1 | 7.31 |
| CHEMBL192789 | — | — | 1 | 7.22 |
| CHEMBL515478 | — | — | 1 | 7.07 |
| CHEMBL479053 | — | — | 1 | 6.96 |
| CHEMBL363398 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477362 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL517675 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL451358 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL479054 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL191941 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL476536 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL516289 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL478415 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL192789 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL515478 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL479053 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL363398 | — | IC50 | = | 480.0 | nM | 6.32 |