Assay Detail
Binding
CHEMBL985701
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Binding affinity to CRF1 receptor in human IMR32 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.45 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484158 | — | — | 1 | 8.92 |
| CHEMBL526149 | — | — | 1 | 8.70 |
| CHEMBL506214 | — | — | 1 | 8.47 |
| CHEMBL475306 | — | — | 1 | 8.33 |
| CHEMBL483993 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484158 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL526149 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL506214 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL475306 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL483993 | — | IC50 | = | 15.2 | nM | 7.82 |