Assay Detail
Functional
CHEMBL985930
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.46 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447991 | — | — | 1 | 10.40 |
| CHEMBL24704 | — | — | 1 | 9.70 |
| CHEMBL284863 | — | — | 1 | 9.30 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.45 |
| CHEMBL508096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447991 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL24704 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL284863 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL508096 | — | IC50 | > | 1000.0 | nM | - |