Assay Detail
Functional
CHEMBL985931
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.86 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506075 | — | — | 1 | 10.52 |
| CHEMBL505378 | — | — | 1 | 9.68 |
| CHEMBL450980 | — | — | 1 | 9.34 |
| CHEMBL507226 | — | — | 1 | 9.30 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.68 |
| CHEMBL446048 | — | — | 1 | 8.34 |
| CHEMBL449370 | — | — | 1 | 8.32 |
| CHEMBL510943 | — | — | 1 | 8.32 |
| CHEMBL504137 | — | — | 1 | 8.22 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.91 |
| CHEMBL445951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506075 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL505378 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL450980 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL507226 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 2.11 | nM | 8.68 |
| CHEMBL446048 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL449370 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL510943 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL504137 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL445951 | — | IC50 | > | 60.0 | nM | - |