Assay Detail
Binding
CHEMBL985935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.83 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475670 | — | — | 1 | 9.43 |
| CHEMBL481213 | — | — | 1 | 9.17 |
| CHEMBL481422 | — | — | 1 | 9.10 |
| CHEMBL472832 | — | — | 1 | 8.90 |
| CHEMBL481421 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475670 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL481213 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL481422 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL472832 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL481421 | — | Ki | = | 29.0 | nM | 7.54 |