Assay Detail
Functional
CHEMBL986250
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Inhibition of phenylephrine-induced aortic ring contraction in Sprague-Dawley rat
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.33 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520828 | — | — | 1 | 6.70 |
| CHEMBL521347 | — | — | 1 | 6.59 |
| CHEMBL384073 | GSK-180736A | — | 1 | 6.12 |
| CHEMBL519680 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520828 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL521347 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL384073 | GSK-180736A | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL519680 | — | IC50 | = | 1300.0 | nM | 5.89 |