Assay Detail
Binding
CHEMBL986292
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Inhibition of human plasma BuchE by Ellman's method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.62 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523830 | — | — | 1 | 8.37 |
| CHEMBL492635 | — | — | 1 | 8.22 |
| CHEMBL523005 | — | — | 1 | 7.92 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.55 |
| CHEMBL492482 | — | — | 1 | 7.55 |
| CHEMBL492898 | — | — | 1 | 7.50 |
| CHEMBL445695 | — | — | 1 | 7.29 |
| CHEMBL492283 | — | — | 1 | 7.24 |
| CHEMBL494684 | — | — | 1 | 7.14 |
| CHEMBL521810 | — | — | 1 | 7.14 |
| CHEMBL492481 | — | — | 1 | 7.06 |
| CHEMBL492233 | — | — | 1 | 6.86 |
| CHEMBL492432 | — | — | 1 | 6.48 |
| CHEMBL492636 | — | — | 1 | 6.45 |
| CHEMBL494519 | — | — | 1 | 6.19 |
| CHEMBL523500 | — | — | 1 | 6.17 |
| CHEMBL521666 | — | — | 1 | 6.16 |
| CHEMBL494887 | TETRAISOPROPYL PYROPHOSPHORAMIDE | — | 1 | 6.13 |
| CHEMBL494520 | — | — | 1 | 6.05 |
| CHEMBL493672 | — | — | 1 | 6.01 |
| CHEMBL521852 | — | — | 1 | 5.60 |
| CHEMBL492430 | — | — | 1 | 5.55 |
| CHEMBL524046 | — | — | 1 | 5.43 |
| CHEMBL494518 | — | — | 1 | 5.41 |
| CHEMBL493460 | — | — | 1 | 5.39 |
| CHEMBL492179 | — | — | 1 | 5.29 |
| CHEMBL464538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523830 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL492635 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL523005 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL492482 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL492898 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL445695 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL492283 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL494684 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL521810 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL492481 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL492233 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL492432 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL492636 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL494519 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL523500 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL521666 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL494887 | TETRAISOPROPYL PYROPHOSPHORAMIDE | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL494520 | — | IC50 | = | 894.0 | nM | 6.05 |
| CHEMBL493672 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL521852 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL492430 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL524046 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL494518 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL493460 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL492179 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL464538 | — | IC50 | = | 255000.0 | nM | - |