Assay Detail

CHEMBL986298

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Binding

Inhibition of human plasma BuchE after 60 mins by carbamylation assay

ChEMBL ↗

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Target

Cholinesterase (CHEMBL1914) ↗

Open DB target context

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Cholinesterase (CHEMBL1914) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cholinesterase

CHEMBL1914

Anchored from Assay target.

Protein identity Cholinesterase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Plasma
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cholinesterase (CHEMBL1914) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.

Carolan CG, Dillon GP, Gaynor JM, Reidy S, Ryder SA, Khan D, Marquez JF, Gilmer JF.
J Med Chem (2008) 51 : 6400 -6409
PubMed 18817366 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.44	8.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL445695	—	—	1	8.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL445695	—	IC50	=	3.6	nM	8.44