Assay Detail
Binding
CHEMBL986727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldose reductase in rat lens homogenate
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.57 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464825 | MANGIFERIN | — | 1 | 5.50 |
| CHEMBL402975 | TINGENIN B | — | 1 | 5.16 |
| CHEMBL432519 | TINGENONE | — | 1 | 4.89 |
| CHEMBL452498 | TRIPTOCALLINE A | — | 1 | 4.85 |
| CHEMBL513961 | — | — | 1 | 4.58 |
| CHEMBL402213 | REGEOL A | — | 1 | 4.52 |
| CHEMBL458310 | MAYTENFOLIC ACID | — | 1 | 4.14 |
| CHEMBL507495 | CELAHIN C | — | 1 | 4.02 |
| CHEMBL516320 | 3-OXO-29-HYDROXYFRIEDELANE | — | 1 | 4.01 |
| CHEMBL459197 | WILFOLIC ACID C | — | 1 | 4.00 |
| CHEMBL514442 | — | — | 1 | - |
| CHEMBL483649 | SALASPERMIC ACID | — | 1 | - |
| CHEMBL515079 | ORTHOSPHENIC ACID | — | 1 | - |
| CHEMBL455098 | beta-AMYRIN | — | 1 | - |
| CHEMBL457951 | — | — | 1 | - |
| CHEMBL461060 | — | — | 1 | - |
| CHEMBL461696 | TRIPTERYGIC ACID A | — | 1 | - |
| CHEMBL518044 | DEMETHYLREGELIN | — | 1 | - |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | - |
| CHEMBL458132 | MAYTENOIC ACID | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL508302 | — | — | 1 | - |
| CHEMBL455365 | — | — | 1 | - |
| CHEMBL399512 | ISOLARICIRESINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464825 | MANGIFERIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL402975 | TINGENIN B | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL432519 | TINGENONE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL452498 | TRIPTOCALLINE A | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL513961 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL402213 | REGEOL A | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL458310 | MAYTENFOLIC ACID | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL507495 | CELAHIN C | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL516320 | 3-OXO-29-HYDROXYFRIEDELANE | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL459197 | WILFOLIC ACID C | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL514442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL483649 | SALASPERMIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL515079 | ORTHOSPHENIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL455098 | beta-AMYRIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL457951 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL461060 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL461696 | TRIPTERYGIC ACID A | IC50 | > | 100000.0 | nM | - |
| CHEMBL518044 | DEMETHYLREGELIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL311498 | CIANIDANOL | IC50 | > | 30000.0 | nM | - |
| CHEMBL458132 | MAYTENOIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL508302 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL455365 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL399512 | ISOLARICIRESINOL | IC50 | > | 100000.0 | nM | - |