Assay Detail
Functional
CHEMBL986777
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Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiinflammatory activity of coumarins from Santolina oblongifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.62 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71851 | SCOPOLETIN | — | 1 | 5.30 |
| CHEMBL244743 | ESCULETIN | — | 1 | 4.96 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.66 |
| CHEMBL225024 | SCOPOLIN | — | 1 | 4.11 |
| CHEMBL49732 | HERNIARIN | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71851 | SCOPOLETIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL244743 | ESCULETIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL225024 | SCOPOLIN | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL49732 | HERNIARIN | IC50 | = | 84000.0 | nM | 4.08 |